Merkel-cell carcinoma (MCC) is a rare and highly aggressive skin cancer, which, in most cases, is caused by the Merkel cell polyomavirus (MCPyV or MCV). Merkel cell carcinoma, also called neuroendocrine carcinoma of the skin or trabecular cancer, is a very rare type of skin cancer that forms when. Los hallazgos clínicos más característicos son el rápido crecimiento y la ausencia de dolor. Aunque el carcinoma de células de Merkel puede afectar cualquier.

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The Journal of Pathology. Several factors are involved in the pathophysiology of MCC, including a virus called Csrcinoma cell polyomavirus MCVultraviolet radiation UV exposure, and weakened immune function.

Infectious diseases — viral systemic diseases A80—B34— Journal of Oral and Maxillofacial Pathology. No specific staging system for Merkel cell carcinoma exists, 7 but the tumor is generally classified as: Ccarcinoma as an adjunct in management of Merkel Cell carcinoma.

[Merkel cell carcinoma experience in a reference medical center.]

J Clin Oncol ; It has an infiltrative growth pattern and spreads by the lymphatic vessels and blood. Merkel-cell carcinoma is a rare skin cancer of neuroendocrine origin, which has been described as the most aggressive skin malignancy.

Inthe annual incidence rate was around 0. Radiotherapy at a dose of 60 Gy also has been used alone, obtaining adequate levels of local control, which supports the characterization of this tumor as radiosensitive. Treatment depends on the disease stage.


Because of MCC’s aggressive local and regional metastatic behavior, radiotherapy is commonly used to treat Merkel-cell cancer. Celupas is a common human infection that can be detected by conformational capsid epitope immunoassays”.

Epidermal nevus Syndromes Epidermal nevus syndrome Schimmelpenning syndrome Nevus comedonicus syndrome Nevus comedonicus Inflammatory linear verrucous epidermal nevus Linear verrucous epidermal nevus Pigmented hairy epidermal nevus syndrome Systematized epidermal nevus Phakomatosis pigmentokeratotica.

European consensus-based interdisciplinary guideline”.

Inmunosupression and Merkel cell cancer. Early diagnosis and treatment of Merkel-cell cancers are important factors in decreasing the chance of metastasis, after which it is exceptionally difficult to cure. By using this site, you agree to the Terms of Use and Privacy Policy. Complete excision is associated with significant higher xe rates.

Carcinoma cutáneo de células de Merkel: Presentación de un caso y revisión de la literatura

Merkel cells; Merkel cancer; Skin cancer. MCV, a polyomavirusis the first polyomavirus strongly suspected to cause tumors in humans. This article contains instructions, advice, or how-to content. The New York Times. It is important to study the extension of the disease when the diagnosis is made.

What Is Merkel Cell Carcinoma?

Safety margins of 2. A clinical case of Merkel cell carcinoma of the face treated with surgery and radiotherapy is reported and the literature is reviewed. Multimodality treatment of Merkel cell carcinoma: Ann Surg Oncol ;8: Another name for MCC is trabecular carcinoma or trabecular cancer. Food and Drug Administration granted accelerated approval to avelumab to treat adults and children above 12 years with metastatic MCC. It is not certain whether surgical excision of the affected lymph nodes is better than radiation treatment alone.


Secondary objectives include preservation of the aesthetic appearance and function. Surgery is usually the first treatment that a patient undergoes for Merkel-cell cancer, especially for the primary tumor. Regular self-examination of the skin should be done every month and a check once a year with a qualified dermatologist.

What Is Merkel Cell Carcinoma?

Merkel cell carcinoma was first described in by Toker, 1 who defined it as a trabecular cell carcinoma. Chemotherapy may be used to treat both primary and metastatic MCC. Diseases of the skin and appendages by morphology. This page was last edited on 28 Octoberat